■ 学術論文
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原著論文
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Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.：NF κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle induced interleukin 1β production: Inhibition of the PM2.5 induced inflammation model.Molecular Medicine Reports 18(6)：5279-5285, 2018.12
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Sidthipong K, Ma J, Yu WL, Wang YF, Kobayashi S, Kishino S, Koide N, Yokochi T, Kato K, Okada S, Umezawa K：Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.Bioorganic & medicinal chemistry letters 27(3)：562-566, 2017.2
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Sosinska,P.;Baum,E.;Mackowiak,B.;Staniszewski,R.;Jasinski,T.;Umezawa,K.;Breborowicz,A.：Inhibition of NF-kappaB with Dehydroxymethylepoxyquinomicin modifies the function of human peritoneal mesothelial cells.American journal of translational research 8(12)：5756-5765, 2016.12
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El-Salhy,M.;Mazzawi,T.;Umezawa,K.;Gilja,O. H.：Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.International journal of molecular medicine 38(6)：1743-1751, 2016.12
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Burgess,J. T.;Bolderson,E.;Adams,M. N.;Baird,A. M.;Zhang,S. D.;Gately,K. A.;Umezawa,K.;O'Byrne,K. J.;Richard,D. J.：Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.Cell death & disease 7(11)：e2469, 2016.11
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Kawaguchi,M.;Yamamoto,K.;Kanemaru,A.;Tanaka,H.;Umezawa,K.;Fukushima,T.;Kataoka,H.：Inhibition of nuclear factor-kappaB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.Oncotarget 7(42)：68614-68622, 2016.10
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Murahashi,M.;Simizu,S.;Morioka,M.;Umezawa,K.：Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.Biochemical and biophysical research communications 476(4)：445-449, 2016.8
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El-Salhy,M.;Umezawa,K.：Effects of AP1 and NFkappaB inhibitors on colonic endocrine cells in rats with TNBSinduced colitis.Molecular medicine reports 14(2)：1515-1522, 2016.8
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Morioka,M.;Kato,K.;Umezawa,K.：Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.The Journal of antibiotics 69(7)：574-578, 2016.7
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El-Salhy,M.;Umezawa,K.：Anti-inflammatory effects of novel AP-1 and NF-kappaB inhibitors in dextran-sulfate-sodium-induced colitis in rats.International journal of molecular medicine 37(6)：1457-1464, 2016.6
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Katsuyama,S.;Sugino,K.;Sasazawa,Y.;Nakano,Y.;Aono,H.;Morishita,K.;Kawatani,M.;Umezawa,K.;Osada,H.;Simizu,S.：Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.FEBS letters 590(8)：1152-1162, 2016.4
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Hirasawa,M.;Takubo,K.;Osada,H.;Miyake,S.;Toda,E.;Endo,M.;Umezawa,K.;Tsubota,K.;Oike,Y.;Ozawa,Y.：Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.The Journal of biological chemistry 291(14)：7373-7385, 2016.4
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Ichikawa,N.;Yamashita,K.;Funakoshi,T.;Ichihara,S.;Fukai,M.;Ogura,M.;Kobayashi,N.;Zaitsu,M.;Yoshida,T.;Shibasaki,S.;Koshizuka,Y.;Tsunetoshi,Y.;Sato,M.;Einama,T.;Ozaki,M.;Umezawa,K.;Suzuki,T.;Todo,S.：Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.Inflammation research : official journal of the European Histamine Research Society ...[et al.] 65(3)：245-260, 2016.3
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El-Salhy,M.;Umezawa,K.：Treatment with novel AP-1 and NF-kappaB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.International journal of molecular medicine 37(3)：556-564, 2016.3
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Wang,Liyan;Lin,Yinzhi;Sidthipong,Kulrawee;Tang,Jianqiang;Li,Mengjie;Koyano,Takashi;Kowithayakorn,Thaworn;Sumiyoshi,Kengo;Ukaji,Tamami;Umezawa,Kazuo：Inhibition of NF-kappa B and cellular invasion by novel flavonoid desmal in ovarian carcinoma cells.Heterocycles 92(2)：353-360, 2016.2
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Okamoto,T.;Ozawa,Y.;Kamoshita,M.;Osada,H.;Toda,E.;Kurihara,T.;Nagai,N.;Umezawa,K.;Tsubota,K.：The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-kappaB Axis during Retinal Inflammation.PloS one 11(1)：e0146517, 2016.1
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Seubwai,W.;Vaeteewoottacharn,K.;Kraiklang,R.;Umezawa,K.;Okada,S.;Wongkham,S.：Inhibition of NF-kappaB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells.Oncology research 23(43102)：21-28, 2016
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Gantsev SK, Umezava K,Vagapova VS;Gantsev KS;Solomenny SV;Kzyrgalin SR;Yamidanov RS;Gantseva EA：Calcification of peritoneum and peritoneal fluid perfusion malfunction in carcinomatosis of serous membranes of peritoneal cavity.Journal of Cancer Research & Therapy 4(4)：31-37, 2016
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Ali,T. F.;Iwamaru,K.;Ciftci,H. I.;Koga,R.;Matsumoto,M.;Oba,Y.;Kurosaki,H.;Fujita,M.;Okamoto,Y.;Umezawa,K.;Nakao,M.;Hide,T.;Makino,K.;Kuratsu,J.;Abdel-Aziz,M.;Abuo-Rahma,Gel-D;Beshr,E. A.;Otsuka,M.：Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system.Bioorganic & medicinal chemistry 23(17)：5476-5482, 2015.9
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Toda,T.;Watanabe,M.;Kawato,J.;Kadin,M. E.;Higashihara,M.;Kunisada,T.;Umezawa,K.;Horie,R.：Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines.British journal of haematology 170(6)：837-846, 2015.9
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Yamanouchi,S.;Adachi,Y.;Shimo,T.;Umezawa,K.;Okigaki,M.;Tsuji,S.;Li,M.;Takaya,J.;Kuge,T.;Ikehara,S.;Kaneko,K.：A nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation.Immunobiology 220(9)：1059-1066, 2015.9
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Zaitsu,M.;Yamashita,K.;Shibasaki,S.;Tsunetoshi,Y.;Fukai,M.;Ogura,M.;Yoshida,T.;Igarashi,R.;Kobayashi,N.;Umezawa,K.;Todo,S.：3-[(Dodecylthiocarbonyl)methyl]-Glutarimide Attenuates Graft Arterial Disease by Suppressing Alloimmune Responses and Vascular Smooth Muscle Cell Proliferation.Transplantation 99(5)：948-956, 2015.5
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Ito,Y.;Kikuchi,E.;Tanaka,N.;Kosaka,T.;Suzuki,E.;Mizuno,R.;Shinojima,T.;Miyajima,A.;Umezawa,K.;Oya,M.：Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer.BMC cancer 15：324-015-1315-9, 2015.4
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Inokawa,S.;Watanabe,T.;Keino,H.;Sato,Y.;Hirakata,A.;Okada,A. A.;Fukuda,K.;Fukushima,A.;Umezawa,K.：Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1beta in human corneal fibroblasts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 253(4)：557-563, 2015.4
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Koide,N.;Kaneda,A.;Yokochi,T.;Umezawa,K.：Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-kappaB inhibitor DTCM-glutarimide.International immunopharmacology 25(1)：162-168, 2015.3
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Sasazawa,Y.;Sato,N.;Umezawa,K.;Simizu,S.：Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.The Journal of biological chemistry 290(10)：6168-6178, 2015.3
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27.
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Mbongue,J. C.;Nicholas,D. A.;Zhang,K.;Kim,N. S.;Hamilton,B. N.;Larios,M.;Zhang,G.;Umezawa,K.;Firek,A. F.;Langridge,W. H.：Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.PloS one 10(2)：e0118562, 2015.2
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Kuboki,M.;Ito,A.;Simizu,S.;Umezawa,K.：Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism.Biochemical and biophysical research communications 456(3)：810-814, 2015.1
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Noma,N.;Asagiri,M.;Takeiri,M.;Ohmae,S.;Takemoto,K.;Iwaisako,K.;Minato,N.;Maeda-Yamamoto,M.;Simizu,S.;Umezawa,K.：Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-kappaB Inhibitor DHMEQ in Mast Cells.International archives of allergy and immunology 166(2)：84-90, 2015
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Horie,K.;Ma,J.;Umezawa,K.：Inhibition of canonical NF-kappaB nuclear localization by (-)-DHMEQ via impairment of DNA binding.Oncology research 22(2)：105-115, 2015
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Haga,S.;Ozawa,T.;Yamada,Y.;Morita,N.;Nagashima,I.;Inoue,H.;Inaba,Y.;Noda,N.;Abe,R.;Umezawa,K.;Ozaki,M.：p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.Antioxidants & redox signaling 21(18)：2515-2530, 2014.12
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Lampiasi,N.;Umezawa,K.;Montalto,G.;Cervello,M.：Poly (ADP-ribose) polymerase inhibition synergizes with the NF-kappaB inhibitor DHMEQ to kill hepatocellular carcinoma cells.Biochimica et biophysica acta 1843(11)：2662-2673, 2014.11
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Matsui,C.;Ikeda,Y.;Iinuma,H.;Kushida,N.;Kunisada,T.;Simizu,S.;Umezawa,K.：Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production.The Journal of antibiotics 67(11)：787-790, 2014.11
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Ukaji,T.;Umezawa,K.：Novel approaches to target NF-kappaB and other signaling pathways in cancer stem cells.Advances in biological regulation 56：108-115, 2014.9
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Koide,N.;Kondo,Y.;Odkhuu,E.;Ulziisaikhan,J.;Ukaji,T.;Yokochi,T.;Umezawa,K.：Inhibition of receptor activator of nuclear factor-kappaB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.Immunology letters 161(1)：31-37, 2014.9
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Seubwai,W.;Wongkham,C.;Puapairoj,A.;Khuntikeo,N.;Pugkhem,A.;Hahnvajanawong,C.;Chaiyagool,J.;Umezawa,K.;Okada,S.;Wongkham,S.：Aberrant expression of NF-kappaB in liver fluke associated cholangiocarcinoma: implications for targeted therapy.PloS one 9(8)：e106056, 2014.8
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Celegato,M.;Borghese,C.;Umezawa,K.;Casagrande,N.;Colombatti,A.;Carbone,A.;Aldinucci,D.：The NF-kappaB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.Cancer letters 349(1)：26-34, 2014.7
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Miyagi,T.;Shiotani,B.;Miyoshi,R.;Yamamoto,T.;Oka,T.;Umezawa,K.;Ochiya,T.;Takano,M.;Tahara,H.：DSE-FRET: A new anticancer drug screening assay for DNA binding proteins.Cancer science 105(7)：870-874, 2014.7
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Goto,Y.;Niwa,Y.;Suzuki,T.;Dohmae,N.;Umezawa,K.;Simizu,S.：C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity.International journal of oncology 45(1)：344-350, 2014.7
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Kamoshita,M.;Ozawa,Y.;Kubota,S.;Miyake,S.;Tsuda,C.;Nagai,N.;Yuki,K.;Shimmura,S.;Umezawa,K.;Tsubota,K.：AMPK-NF-kappaB axis in the photoreceptor disorder during retinal inflammation.PloS one 9(7)：e103013, 2014.7
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Nishio,H.;Yaguchi,T.;Sugiyama,J.;Sumimoto,H.;Umezawa,K.;Iwata,T.;Susumu,N.;Fujii,T.;Kawamura,N.;Kobayashi,A.;Park,J.;Aoki,D.;Kawakami,Y.：Immunosuppression through constitutively activated NF-kappaB signalling in human ovarian cancer and its reversal by an NF-kappaB inhibitor.British journal of cancer 110(12)：2965-2974, 2014.6
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Ukaji,T.;Sasazawa,Y.;Umezawa,K.;Simizu,S.：Involvement of conserved tryptophan residues for secretion of TIMP-2.Oncology letters 7(3)：631-634, 2014.3
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Togano,T.;Watanabe,M.;Itoh,K.;Umezawa,K.;Masuda,N.;Higashihara,M.;Horie,R.：Activation of Akt involves resistance to NF-kappaB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells.Lung cancer (Amsterdam, Netherlands) 83(2)：139-145, 2014.2
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El-Salhy,M.;Umezawa,K.;Gilja,O. H.;Hatlebakk,J. G.;Gundersen,D.;Hausken,T.：Amelioration of severe TNBS induced colitis by novel AP-1 and NF- kappa B inhibitors in rats.TheScientificWorldJournal 2014：813804, 2014.1
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Watanabe,M.;Umezawa,K.;Higashihara,M.;Horie,R.：Combined inhibition of NF-kappaB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.Oncology research 21(4)：173-180, 2013
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Sato,M.;Nakanishi,K.;Haga,S.;Fujiyoshi,M.;Baba,M.;Mino,K.;Yimin;Niwa,H.;Yokoo,H.;Umezawa,K.;Ohmiya,Y.;Kamiyama,T.;Todo,S.;Taketomi,A.;Ozaki,M.：Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappaB inhibitor, (-)-DHMEQ.Oncology research 21(6)：333-343, 2013
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5件表示
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全件表示(46件)
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