■ 学術論文
原著論文
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Tomoko Higuchi, Daisuke Suzuki, Takafumi Watanabe, Kanda Fanhchaksai, Keiko Ota, Kazuhisa Yokoo, Hiroshi Furukawa, Hideto Watanabe.:Versican contributes to ligament formation of knee joints.PloS one 16(4):e0250366, 2021.4
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Sugiura,N.;Clausen,T. M.;Shioiri,T.;Gustavsson,T.;Watanabe,H.;Salanti,A.:Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library.Glycoconjugate journal 33(6):985-994, 2016.12
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Clausen,T. M.;Pereira,M. A.;Oo,H. Z.;Resende,M.;Gustavson,T.;Mao,Y.;Sugiura,N.;Liew,J.;Fazli,L.;Theander,T. G.;Daugaard,M.;Salanti,A.:Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting.Sensing and Bio-Sensing Research 9:23-30, 2016.7
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Shioiri,T.;Tsuchimoto,J.;Watanabe,H.;Sugiura,N.:Sequence determination of synthesized chondroitin sulfate dodecasaccharides.Glycobiology 26(6):592-606, 2016.6
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Iohara,K.;Fujita,M.;Ariji,Y.;Yoshikawa,M.;Watanabe,H.;Takashima,A.;Nakashima,M.:Assessment of Pulp Regeneration Induced by Stem Cell Therapy by Magnetic Resonance Imaging.Journal of endodontics 42(3):397-401, 2016.3
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Fanhchaksai,K.;Okada,F.;Nagai,N.;Pothacharoen,P.;Kongtawelert,P.;Hatano,S.;Makino,S.;Nakamura,T.;Watanabe,H.:Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth.International journal of cancer 138(3):630-641, 2016.2
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Koga,H.;Fujitani,H.;Morino,Y.;Miyamoto,N.;Tsuchimoto,J.;Shibata,T. F.;Nozawa,M.;Shigenobu,S.;Ogura,A.;Tachibana,K.;Kiyomoto,M.;Amemiya,S.;Wada,H.:Experimental Approach Reveals the Role of alx1 in the Evolution of the Echinoderm Larval Skeleton.PloS one 11(2):e0149067, 2016.2
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Yamahara,M.;Sugimura,K.;Kumagai,A.;Fuchino,H.;Kuroi,A.;Kagawa,M.;Itoh,Y.;Kawahara,H.;Nagaoka,Y.;Iida,O.;Kawahara,N.;Takemori,H.;Watanabe,H.:Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.Journal of natural medicines 70(1):28-35, 2016.1
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Tsuchimoto,J.;Yamaguchi,M.:Hox expression in the direct-type developing sand dollar Peronella japonica.Developmental dynamics : an official publication of the American Association of Anatomists 243(8):1020-1029, 2014.8
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Ishimaru,D.;Sugiura,N.;Akiyama,H.;Watanabe,H.;Matsumoto,K.:Alterations in the chondroitin sulfate chain in human osteoarthritic cartilage of the knee.Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 22(2):250-258, 2014.2
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Kawaguchi,Y.;Sugiura,N.;Kimata,K.;Kimura,M.;Kakuta,Y.:The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein.FEBS letters 587(24):3943-3948, 2013.12
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Sugiura,N.;Ikeda,M.;Shioiri,T.;Yoshimura,M.;Kobayashi,M.;Watanabe,H.:Chondroitinase from baculovirus Bombyx mori nucleopolyhedrovirus and chondroitin sulfate from silkworm Bombyx mori.Glycobiology 23(12):1520-1530, 2013.12
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Sato,Y.;Shimono,C.;Li,S.;Nakano,I.;Norioka,N.;Sugiura,N.;Kimata,K.;Yamada,M.;Sekiguchi,K.:Nephronectin binds to heparan sulfate proteoglycans via its MAM domain.Matrix biology : journal of the International Society for Matrix Biology 32(43163):188-195, 2013.4
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Jinno-Oue,A.;Tanaka,A.;Shimizu,N.;Mori,T.;Sugiura,N.;Kimata,K.;Isomura,H.;Hoshino,H.:Inhibitory effect of chondroitin sulfate type e on the binding step of human T-cell leukemia virus type 1.AIDS Research and Human Retroviruses 29(3):621-629, 2013.3
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Shimbo,M.;Ando,S.;Sugiura,N.;Kimata,K.;Ichijo,H.:Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones.Brain research 1491:34-43, 2013.1
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杉浦 信夫:囲食膜のコンドロイチン硫酸とバキュロウイルスのコンドロイチン分解酵素.蚕糸・昆虫バイオテック 82:109-115, 2013
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Sugiura,N.;Shioiri,T.;Chiba,M.;Sato,T.;Narimatsu,H.;Kimata,K.;Watanabe,H.:Construction of a chondroitin sulfate library with defined structures and analysis of molecular interactions.The Journal of biological chemistry 287:43390-43400, 2012.11
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Sobhany,M.;Kakuta,Y.;Sugiura,N.;Kimata,K.;Negishi,M.:The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis.The Journal of biological chemistry 287(43):36022-36028, 2012.10
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Hatano,S.;Kimata,K.;Hiraiwa,N.;Kusakabe,M.;Isogai,Z.;Adachi,E.;Shinomura,T.;Watanabe,H.:Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development.Glycobiology 22(9):1268-1277, 2012.9
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Mori,T.;Kodera,T.;Yoshimine,H.;Kakuta,Y.;Sugiura,N.;Kimata,K.;Okahata,Y.:Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance.Chemistry a European Journal 18(24):7388-7393, 2012.6
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Kawaguchi,Y.;Sugiura,N.;Onishi,M.;Kimata,K.;Kimura,M.;Kakuta,Y.:Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66.Acta crystallographica.Section F, Structural biology and crystallization communications 68(Pt 2):190-192, 2012.2
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Ogawa,H.;Hatano,S.;Sugiura,N.;Nagai,N.;Sato,T.;Shimizu,K.;Kimata,K.;Narimatsu,H.;Watanabe,H.:Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.PloS one 7(8):e43806 1-12, 2012
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Imagama,S.;Sakamoto,K.;Tauchi,R.;Shinjo,R.;Ohgomori,T.;Ito,Z.;Zhang,H.;Nishida,Y.;Asami,N.;Takeshita,S.;Sugiura,N.;Watanabe,H.;Yamashita,T.;Ishiguro,N.;Matsuyama,Y.;Kadomatsu,K.:Keratan sulfate restricts neural plasticity after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience 31(47):17091-17102, 2011.11
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Shimokawa,K.;Kimura-Yoshida,C.;Nagai,N.;Mukai,K.;Matsubara,K.;Watanabe,H.;Matsuda,Y.;Mochida,K.;Matsuo,I.:Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.Developmental cell 21(2):257-272, 2011.8
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Sugiura,N.;Setoyama,Y.;Chiba,M.;Kimata,K.;Watanabe,H.:Baculovirus envelope protein ODV-E66 is a novel chondroitinase with distinct substrate specificity.The Journal of biological chemistry 286(33):29026-29034, 2011.8
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Sato,T.;Kudo,T.;Ikehara,Y.;Ogawa,H.;Hirano,T.;Kiyohara,K.;Hagiwara,K.;Togayachi,A.;Ema,M.;Takahashi,S.;Kimata,K.;Watanabe,H.;Narimatsu,H.:Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.The Journal of biological chemistry 286(7):5803-5812, 2011.2
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Kato,D.;Era,S.;Watanabe,I.;Arihara,M.;Sugiura,N.;Kimata,K.;Suzuki,Y.;Morita,K.;Hidari,K. I.;Suzuki,T.:Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein.Antiviral Research 88(2):236-243, 2010.11
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Ogawa,Hiroyasu;Shionyu,Masafumi;Sugiura,Nobuo;Hatano,Sonoko;Nagai,Naoko;Kubota,Yukihiko;Nishiwaki,Kiyoji;Sato,Takashi;Gotoh,Masanori;Narimatsu,Hisashi;Shimizu,Katsuji;Kimata,Koji;Watanabe,Hideto:Chondroitin Sulfate Synthase-2/Chondroitin Polymerizing Factor Has Two Variants with Distinct Function.Journal of Biological Chemistry 285(44):34155-34167, 2010.10
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Li,S.;Shimono,C.;Norioka,N.;Nakano,I.;Okubo,T.;Yagi,Y.;Hayashi,M.;Sato,Y.;Fujisaki,H.;Hattori,S.;Sugiura,N.;Kimata,K.;Sekiguchi,K.:Activin a binds to perlecan through its pro-region that has heparin/heparan sulfate-binding activity.The Journal of biological chemistry :*, 2010.9
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Choocheep,Kanyamas;Hatano,Sonoko;Takagi,Hidekazu;Watanabe,Hiroki;Kimata,Koji;Kongtawelert,Prachya;Watanabe,Hideto:Versican Facilitates Chondrocyte Differentiation and Regulates Joint Morphogenesis.Journal of Biological Chemistry 285(27):21114-21125, 2010.7
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Kioka,N.;Ito,T.;Yamashita,H.;Uekawa,N.;Umemoto,T.;Motoyoshi,S.;Imai,H.;Takahashi,K.;Watanabe,H.;Yamada,M.;Ueda,K.:Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo.Experimental cell research 316(10):1728-1738, 2010.6
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Ando,S.;Sugiura,N.;Kimata,K.;Ichijo,H.:Influences of retinal axons on the cultural substrate containing biotin-conjugated chondroitin sulfate in vitro.Anatomical science international / Japanese Association of Anatomists :*, 2010.3
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Sugiura,N.;Baba,Y.;Kawaguchi,Y.;Iwatani,T.;Suzuki,K.;Kusakabe,T.;Yamagishi,K.;Kimata,K.;Kakuta,Y.;Watanabe,H.:Glucuronyltransferase activity of KfiC from Escherichia coli strain K5 requires association of KfiA: KfiC and KfiA are essential enzymes for production of K5 polysaccharide, N-acetylheparosan.The Journal of biological chemistry 285(3):1597-1606, 2010.1
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Zhu,Long;Zhuo,Lisheng;Kimata,Koji;Yamaguchi,Etsuro;Watanabe,Hideto;Aronica,Mark A.;Hascall,Vincent C.;Baba,Kenji:Deficiency in the Serum-Derived Hyaluronan-Associated Protein-Hyaluronan Complex Enhances Airway Hyperresponsiveness in a Murine Model of Asthma.International archives of allergy and immunology 153(3):223-233, 2010
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Ashikari-Hada,S.;Habuchi,H.;Sugaya,N.;Kobayashi,T.;Kimata,K.:Specific inhibition of FGF-2 signaling with 2-O-sulfated octasaccharides of heparan sulfate.Glycobiology 19(6):644-54, 2009.6
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36.
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Muramatsu,K.;Kusafuka,K.;Watanabe,H.;Mochizuki,T.;Nakajima,T.:Ultrastructural immunolocalization of a cartilage-specific proteoglycan, aggrecan, in salivary pleomorphic adenomas.Medical molecular morphology 42(1):47-54, 2009.3
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Suwan,K.;Choocheep,K.;Hatano,S.;Kongtawelert,P.;Kimata,K.;Watanabe,H.:Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts.The Journal of biological chemistry 284(13):8596-604, 2009.3
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38.
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Osawa,T.;Sugiura,N.;Shimada,H.;Hirooka,R.;Tsuji,A.;Shirakawa,T.;Fukuyama,K.;Kimura,M.;Kimata,K.;Kakuta,Y.:Crystal structure of chondroitin polymerase from Escherichia coli K4.Biochemical and biophysical research communications 378(1):10-14, 2009.1
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Suwan,K.;Hatano,S.;Kongtawelert,P.;Pothacharoen,P.;Watanabe,H.:Alteration of chondroitin sulfate composition on proteoglycan produced by knock-in mouse embryonic fibroblasts whose versican lacks the A subdomain.Upsala journal of medical sciences 114(2):73-81, 2009
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Sobhany,M.;Kakuta,Y.;Sugiura,N.;Kimata,K.;Negishi,M.:The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites.The Journal of biological chemistry 283(47):32328-33, 2008.11
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Manabe,R.;Tsutsui,K.;Yamada,T.;Kimura,M.;Nakano,I.;Shimono,C.;Sanzen,N.;Furutani,Y.;Fukuda,T.;Oguri,Y.;Shimamoto,K.;Kiyozumi,D.;Sato,Y.;Sado,Y.;Senoo,H.;Yamashina,S.;Fukuda,S.;Kawai,J.;Sugiura,N.;Kimata,K.;Hayashizaki,Y.;Sekiguchi,K.:Transcriptome-based systematic identification of extracellular matrix proteins.Proceedings of the National Academy of Sciences of the United States of America 105(35):12849-54, 2008.9
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Sugiura,N.;Shimokata,S.;Minamisawa,T.;Hirabayashi,J.;Kimata,K.;Watanabe,H.:Sequential synthesis of chondroitin oligosaccharides by immobilized chondroitin polymerase mutants.Glycoconjugate journal 25(6):521-30, 2008.8
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43.
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Fujiwara,T.;Kawakatsu,T.;Tayama,S.;Kobayashi,Y.;Sugiura,N.;Kimata,K.;Takai,Y.:Hyaluronan-CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells.Genes to cells : devoted to molecular & cellular mechanisms 13(7):759-70, 2008.7
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44.
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Zhu,L.;Zhuo,L.;Watanabe,H.;Kimata,K.:Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan.Connective tissue research 49(1):48-55, 2008
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45.
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Sugaya,N.;Habuchi,H.;Nagai,N.;Ashikari-Hada,S.;*Kimata,K.:6-O-Sulfation of Heparan Sulfate Differentially Regulates Various Fibroblast Growth Factor-dependent Signalings in Culture.Journal Biological Chemistry 283(16):10366-76, 2008
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Watanabe,H.;Shionyu,M.;Kimura,T.;Kimata,K.;Watanabe,H.:Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation.The Journal of biological chemistry 282(28):20728-38, 2007.7
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Sugiura,N.;Shimokata,S.;Watanabe,H.;Kimata,K.:MS analysis of chondroitin polymerization: effects of Mn2+ ions on the stability of UDP-sugars and chondroitin synthesis.Analytical Biochemistry 365(1):62-73, 2007.6
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48.
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Sakai,K.;Kimata,K.;Sato,T.;Gotoh,M.;Narimatsu,H.;Shinomiya,K.;Watanabe,H.:Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.The Journal of biological chemistry 282(6):4152-61, 2007.2
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Habuchi,H.;Nagai,N.;Sugaya,N.;Atsumi,F.;Stevens,R. L.;Kimata,K.:Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.Journal Biological Chemistry 282:15578-88, 2007
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Nagai,N.;Habuchi,H.;Kitazume,S.;Toyoda,H.;Hashimoto,Y.;Kimata,K.:Regulation of heparan sulfate 6-O-sulfation by beta-secretase activity.Journal of Biological Chemistry 282(20):14942-51, 2007
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51.
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Minamisawa,T.;Suzuki,K.;Maeda,H.;Shimokata,S.;Sugiura,N.;Kimata,K.;Hirabayashi,J.:Characterization of isomeric unsulfated glycosaminoglycan oligosaccharides by mass spectrometry/mass spectrometry.Journal of the Mass Spectrometry Society of Japan 55(1):1-6, 2007
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5件表示
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全件表示(51件)
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症例報告
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Kusafuka,K.;Muramatsu,K.;Kasami,M.;Kuriki,K.;Hirobe,K.;Hayashi,I.;Watanabe,H.;Hiraki,Y.;Shukunami,C.;Mochizuki,T.;Kameya,T.:Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 21(10):1282-92, 2008.10
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総説
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1.
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Ichijo,H.;Sugiura,N.;Kimata,K.:Application of chondroitin sulfate derivatives for understanding axonal guidance in the nervous system during development.Polymers 5:254-268, 2013
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2.
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渡辺秀人:【癌の転移因子】 細胞外マトリックスと浸潤・転移(解説/特集).癌と化学療法 37(11):2058-2061, 2010.11
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3.
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永井尚子;木全弘治:ヘパラン硫酸による高分子リガンドの細胞内取り込み機構.蛋白質核酸酵素 53(12):1564-9, 2008
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レター
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1.
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Kusafuka,K.;Watanabe,H.;Kimata,K.;Hiraki,Y.;Shukunami,C.;Kameya,T.:Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination.Histopathology 51(2):258-61, 2007.8
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報告書
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1.
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杉浦信夫:コンドロイチン硫酸の高硫酸化活性ドメインの酵素合成とその生体内機能の解明.平成23-25年度科学研究費補助金基盤研究(C)研究成果報告書 :*, 2014
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杉浦信夫:組換え酵素を用いた人工コンドロイチン硫酸の合成と生理機能の解明.平成19-20年度科学研究費補助金若手研究(スタートアップ)研究成果報告書 :*, 2009.5
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