論文種別	症例報告
言語種別	英語
表題	Clostridium Perfringens Infection in a Febrile Patient with Severe Hemolytic Anemia
掲載誌名	正式名：The American journal of case reports 略　 称：Am.J.Case Rep. ISSNコード：1941-5923/1941-5923
出版社	（United States）
巻・号・頁	17,pp.219-223
著者・共著者	Hashiba,M.;Tomino,A.;Takenaka,N.;Hattori,T.;Kano,H.;Tsuda,M.;Takeyama,N.
発行年月	2016/04
概要	2016 Apr 6. BACKGROUND: Clostridium perfringens (C. perfringens) can cause various infections, including gas gangrene, crepitant cellulitis, and fasciitis. While C. perfringens sepsis is uncommon, it is often rapidly fatal because the alpha toxin of this bacterium induces massive intravascular hemolysis by disrupting red blood cell membranes. CASE REPORT: We present the case of a male patient with diabetes who developed a fatal liver abscess with massive intravascular hemolysis and septic shock caused by toxigenic C. perfringens. The peripheral blood smear showed loss of central pallor, with numerous spherocytes. Multiplex PCR only detected expression of the cpa gene, indicating that the pathogen was C. perfringens type A. CONCLUSIONS: C. perfringens infection should be considered in a febrile patient who has severe hemolytic anemia with a very low MCV, hemolyzed blood sample, and negative Coombs test. The characteristic peripheral blood smear findings may facilitate rapid diagnosis.
文献番号	PMC4824343
PMID	27049736