論文種別	その他
言語種別
表題	Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice.
掲載誌名	正式名：The Journal of cell biology 略　 称：J Cell Biol
掲載区分	国外
巻・号・頁	169(3),527-38頁
著者・共著者	Miyamoto Tatsuo, Morita Kazumasa, Takemoto Daisuke, Takeuchi Kosei, Kitano Yuka, Miyakawa Tsuyoshi, Nakayama Kiyomi, Okamura Yasushi, Sasaki Hiroyuki, Miyachi Yoshiki, Furuse Mikio, Tsukita Shoichiro
発行年月	2005/05
概要	Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological "sealing" function of Schwann cells.
NAID	15883201